Steven P Gygi Selected Research

Cullin 1

3/2011	SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction.
9/2010	Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction.

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Steven P Gygi Research Topics

Disease

61	Neoplasms (Cancer) 02/2022 - 08/2003
12	Inflammation (Inflammations) 01/2022 - 07/2012
12	Obesity 01/2021 - 08/2009
10	Infections 01/2021 - 03/2002
8	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2022 - 02/2008
8	Insulin Resistance 01/2018 - 01/2010
7	Alzheimer Disease (Alzheimer's Disease) 01/2022 - 02/2004
7	Breast Neoplasms (Breast Cancer) 01/2021 - 10/2004
7	Carcinogenesis 12/2020 - 09/2004
6	Fanconi Anemia (Fanconi's Anemia) 01/2020 - 04/2007
6	Genomic Instability 01/2018 - 12/2008
5	Mitochondrial Diseases (Mitochondrial Disease) 03/2022 - 08/2009
5	Neoplasm Metastasis (Metastasis) 10/2017 - 10/2010
5	Parkinson Disease (Parkinson's Disease) 11/2014 - 05/2005
4	Ovarian Neoplasms (Ovarian Cancer) 12/2021 - 08/2003
4	Starvation 11/2021 - 11/2003
4	Lung Neoplasms (Lung Cancer) 01/2020 - 12/2007
4	Hypoxia (Hypoxemia) 10/2017 - 07/2009
4	Type 2 Diabetes Mellitus (MODY) 10/2017 - 01/2013
3	Colonic Neoplasms (Colon Cancer) 01/2022 - 03/2011
3	Leukemia 01/2021 - 04/2011
3	Pancreatic Neoplasms (Pancreatic Cancer) 01/2020 - 12/2016
3	Melanoma (Melanoma, Malignant) 01/2020 - 12/2016
3	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2018 - 07/2015
2	Multiple Myeloma 03/2022 - 01/2021
2	Cognitive Dysfunction 01/2022 - 01/2020
2	Acquired Immunodeficiency Syndrome (AIDS) 01/2022 - 04/2009
2	Triple Negative Breast Neoplasms 01/2022 - 03/2011
2	Cardiomyopathies (Cardiomyopathy) 01/2021 - 03/2014
2	Hypertrophy 01/2019 - 11/2014
2	Spinal Muscular Atrophy (Progressive Muscular Atrophy) 12/2018 - 01/2018
2	Malaria 01/2018 - 05/2015
2	Hepatocellular Carcinoma (Hepatoma) 01/2018 - 01/2017
2	Cytomegalovirus Infections (Inclusion Disease) 01/2017 - 04/2013
2	Tuberculosis (Tuberculoses) 01/2017 - 04/2015
2	Adenocarcinoma 01/2017 - 11/2015
2	Bardet-Biedl Syndrome (Syndrome, Bardet-Biedl) 11/2014 - 06/2010

Drug/Important Bio-Agent (IBA)

62	Proteins (Proteins, Gene)FDA Link 01/2022 - 08/2003
17	Phosphotransferases (Kinase)IBA 12/2020 - 12/2007
13	Glucose (Dextrose)FDA LinkGeneric 03/2022 - 07/2009
11	DNA (Deoxyribonucleic Acid)IBA 01/2022 - 04/2007
10	ProteomeIBA 01/2022 - 07/2014
7	UbiquitinIBA 11/2016 - 02/2008
6	Tyrosine (L-Tyrosine)FDA Link 02/2022 - 12/2007
6	Mechanistic Target of Rapamycin Complex 1IBA 11/2021 - 06/2011
5	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 01/2022 - 09/2010
5	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2017 - 09/2010
5	Amino Acids FDA Link 01/2017 - 11/2003
5	Ligases (Synthetase)IBA 11/2014 - 06/2009
4	Peptides (Polypeptides)IBA 02/2022 - 11/2015
4	Pharmaceutical PreparationsIBA 02/2022 - 12/2007
4	Transcription Factors (Transcription Factor)IBA 01/2021 - 07/2012
4	Biological ProductsIBA 12/2020 - 10/2004
4	Oncogene Proteins (Oncogene Protein)IBA 01/2020 - 03/2011
4	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2018 - 01/2015
4	Glutamine (L-Glutamine)FDA Link 01/2017 - 08/2010
3	RNA (Ribonucleic Acid)IBA 01/2022 - 01/2018
3	Antiviral Agents (Antivirals)IBA 11/2021 - 01/2020
3	Fatty Acids (Saturated Fatty Acids)IBA 12/2020 - 05/2014
3	HeterochromatinIBA 01/2020 - 03/2007
3	Amyloid beta-PeptidesIBA 01/2020 - 10/2008
3	Histones (Histone)IBA 01/2020 - 03/2007
3	LigandsIBA 01/2019 - 11/2014
3	CyclinsIBA 01/2018 - 06/2011
3	EnzymesIBA 01/2018 - 11/2016
3	Messenger RNA (mRNA)IBA 10/2017 - 04/2009
3	Biomarkers (Surrogate Marker)IBA 01/2016 - 08/2003
3	MitogensIBA 01/2015 - 07/2009
3	Protein Isoforms (Isoforms)IBA 11/2014 - 09/2004
3	Cyclin D1IBA 01/2014 - 01/2010
3	IsotopesIBA 04/2011 - 07/2004
3	Deubiquitinating EnzymesIBA 10/2010 - 12/2007
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 02/2022 - 01/2021
2	InterferonsIBA 01/2022 - 10/2016
2	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2022 - 07/2014
2	EpitopesIBA 01/2022 - 09/2017
2	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 01/2022 - 12/2007
2	Succinic Acid (Succinate)IBA 01/2021 - 01/2018
2	Uncoupling Protein 1IBA 01/2021 - 07/2013
2	ChromatinIBA 01/2021 - 01/2020
2	CytokinesIBA 01/2021 - 01/2021
2	Adenosine Triphosphate (ATP)IBA 01/2020 - 03/2014
2	CarbonIBA 01/2020 - 01/2019
2	Cyclin-Dependent Kinase 5IBA 01/2020 - 11/2014
2	Mechanistic Target of Rapamycin Complex 2IBA 01/2019 - 11/2013
2	Viral ProteinsIBA 01/2019 - 06/2014
2	Cyclin EIBA 01/2018 - 03/2011
2	Mitogen-Activated Protein KinasesIBA 01/2018 - 01/2015
2	Small Interfering RNA (siRNA)IBA 01/2018 - 03/2007
2	Lysine (L-Lysine)FDA Link 01/2018 - 02/2008
2	Nicotine FDA Link 01/2018 - 10/2015
2	Retinaldehyde (Retinal)IBA 10/2017 - 01/2016
2	MTOR InhibitorsIBA 08/2017 - 04/2012
2	AdipokinesIBA 11/2015 - 11/2014
2	ClathrinIBA 11/2015 - 06/2010
2	AdiponectinIBA 11/2015 - 11/2014
2	Hormones (Hormone)IBA 11/2015 - 01/2013
2	Membrane Proteins (Integral Membrane Proteins)IBA 07/2015 - 06/2010

Therapy/Procedure

17	Therapeutics 03/2022 - 12/2007
3	Immunotherapy 01/2022 - 01/2019